Primary osseous rosai-dorfman disease without lymphadenopathy: A case report on rare entity

Vol 32| Issue 1 | Jan – June 2019 | page: 34-37 | Sukesh A N, Lazar J Chandy, Dennis P Jose, Pushpa Mahadevan


Authors: Sukesh A N [1], Lazar J Chandy [1], Dennis P Jose [1], Pushpa Mahadevan [2]

[1] Department of Orthopaedics, VPS Lakeshore Hospital, Kochi, Kerala, India.
[2] Department of Pathology, VPS Lakeshore Hospital, Kochi, Kerala, India.

Address of Correspondence

Dr. Sukesh A N,
Department of Orthopaedics, VPS Lakeshore Hospital, Kochi, Kerala, India
E-mail: Sukesh_an@yahoo.com


Abstract

Introduction: Primary osseous Rosai-Dorfman Disease (RDD) is an unusual manifestation of a rare non- malignant histiocytic proliferative disease. A disease primarily of lymph node sinus with 40% extra nodal involvement . Extra nodal manifestations can occur without lymphadenopathy (28%). Isolated skeletal involvement is very rare, occurring only in 2-8% of all the patients reported to date .

Keywords: Emperipolesis, Lymphadenopathy, Rosai-Dorfman Disease.


References

1. J. Rosai and R. F. Dorfman, “Sinus histiocytosis with mas- sive lymphadenopathy. A newly recognized benign clinico- pathological entity,” Archives of pathology, vol. 87, no. 1, pp. 63–70, 1969.
2. Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol. 1990; 7:19–73.
3. B. A. Mosheimer, B. Oppl, S. Zandieh et al., “Bone in- volvement in Rosai-Dorfman disease (RDD): a case report and systematic literature review,” Current Rheumatology Reports, vol. 19, no. 5, p. 29, 2017.
4. E. G. Demicco, A. E. Rosenberg, J. Bjornsson, L. D. Rybak, K. K. Unni, and G. P. Nielsen, “Primary Rosai-Dorfman disease of bone: a clinicopathologic study of 15 cases,” American Journal of Surgical Pathology, vol. 34, no. 9, pp. 1324–1333, 2010.
5. Humble JG, Jayne WHW, Pulvertaft RJV. Biological interaction between lymphocytes and other cells. Br J Haematol. 1956;2:283-94
6. Rastogi, V. Emperipolesis-A Review.Journal of Clinical and Diagnostic Research.2014
7. Sundaram C, UppinShantveer G, Chandrashekar P, et al. Multi- focal osseous involvement as the sole manifestation of Rosai- Dorfman disease. Skeletal Radiol. 2005; 34:658–664.
8. George J, Stacy G, Peabody T, Montag A. Rosai-Dorfman disease manifesting as a solitary lesion of the radius in a 41-year-old woman. Skeletal Radiol. 2003;32(4):236e239

9. Patterson FR, Rooney MT, Damron TA, et al. Sclerotic lesion of the tibia without involvement of lymph nodes. Report of an unusual case of Rosai-Dorfman disease. J Bone Joint Surg Am. 1997; 79:911–916

10. Park YK, Kim YW, Choi WS, et al. Sinus histiocytosis with massive lymphadenopathy. Multiple skull involvements. J Korean Med Sci. 1998; 13:423–427.


How to Cite this Article: Sukesh A N, Chandy L J, Jose D P, Mahadevan P. Primary osseous Rosai-Dorfman disease without lymphadenopathy: A case report on rare entity. Kerala Journal of Orthopaedics Jan-June 2019; 32(1): 34-37 .

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